Dupont is focusing on food and agricultural products to cut its dependence on a weakening market for paint pigments.
The company expects its first-half operating earnings per share to be about 10 percent below last year, Chief Financial Officer Nicholas Fanandakis said in a statement on Thursday. The company had forecast a 7 to 9 percent fall in April.
"Unseasonably cool, wet weather across North America and Europe is impacting our agriculture and nutrition and health segments' second-quarter revenues and costs," Fanandakis said.
The company also expects full-year operating earnings to be at the low end of its forecast of $3.85 to $4.05 per share.
DuPont's agricultural business accounted for 45 percent of its first-quarter revenue of $10.4 billion.
The company will report second-quarter results on July 23.
The stock was trading at $53.43 on the New York Stock Exchange on Thursday morning.