The study, published in the Journal of Internal Medicine , evaluated the use of magnetic resonance imaging (MRI) and measures of plasma levels of vitamin E forms - including all eight natural vitamin E congeners (four tocopherols and four tocotrienols) - in differentiating individuals with Alzheimer's disease (AD) and mild cognitive impairment (MCI) from cognitively intact control (CTL) subjects.
Consistent with previous research findings, the new study – led by Francesca Mangialasche from the Karolinska Institutet, Sweden – reports that both AD and MCI patients had lower blood plasma levels of different vitamin E isomers, compared to CTL subjects.
“Plasma levels of tocopherols and tocotrienols together with automated MRI measures can help to differentiate AD and MCI patients from CTL subjects, and to prospectively predict MCI conversion into AD,” said Mangialasche and her colleagues.
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