The JECFA determinations will also enable regulatory approvals in other countries across the world.
All four of the flavor modifiers, which were discovered and developed by Senomyx, have earlier received Generally Recognized As Safe (GRAS) regulatory status in the US.
Senomyx chief executive officer Kent Snyder said the positive JECFA determinations for the flavor modifiers are significant achievements for the company.
"From a practical perspective the approvals resulting from the JECFA safety determinations, along with the GRAS status, open many markets for S6973, S2383, S6821 and S7958. Notable exceptions are countries in the European Union and China, which have their own regulatory processes," Snyder added.