Seaboard Foods and Triumph Foods will build a new pork processing facility in Sioux City, Iowa that is expected to create 1,100 jobs.
Both companies have committed $264m for the project, reports Sioux City Journal.
The facility will manufacture a full line of fresh pork products for international, retail, food service and processing markets.
Seaboard Foods markets and sells fresh pork that is processed at Triumph Foods' Missouri and Oklahoma plants.
The company markets and sells its products under the PrairieFresh Premium Pork brand, and under the Seaboard Farms and St Joe Pork brands in the international market.
The construction of the facility is expected to be completed by July 2017. Once complete, it will process an estimated three million market hogs every year through a single shift.
Seaboard Foods CEO Terry Holton said: "Today's announcement marks another step in strengthening our business partnership and position as a leading integrated food system, providing customers domestically and throughout the world with premium pork, focused on the highest standards for food safety and pork quality consistency."
The company selected Sioux City for the facility owing to its industrial site location, transportation infrastructure, availability of market hogs in the region and the pro-business environment city leaders, the Iowa Economic Development Authority and the state of Iowa, Seaboard Foods said in a statement.
Triumph Foods CEO Mark Campbell said: "When we started inquiring about expanding our business, we recognised the strong commitment and willingness to welcome Triumph Foods and Seaboard Foods to the city.
"Local leaders have built a business environment poised to bring growth to the region. We look forward to the new pork processing facility being part of that growth, and its staff being actively involved in the Sioux City community."