The move is part of the company's strategy to improve the nutritional and ingredient profile of its products while maintaining the taste.
The company will remove artificial flavors from over 250 products under six brands including Digiorno, Tombstone, California Pizza Kitchen, Jack's, Hot Pockets and Lean Pockets, while reducing the sodium content.
Nestle USA Pizza & Snacking Division president John Carmichael said: "We know people want to feel good about the foods they eat, and they're seeking foods made with fewer artificial ingredients and less sodium.
"As one of the nation's largest food companies, Nestlé is listening to consumers and delivering on their desire for convenient, great-tasting foods that have an improved nutritional profile."
The company said that its products set to launch this spring and summer will contain less sodium and no artificial colors. This includes California Pizza Kitchen Gluten-Free Crispy Thin Crust pizzas, Digiorno Pizzeria! Thin, Hot Pockets Snack Bites and Breakfast Bites, Tombstone Limited Edition Diablo and Bratwurst pizzas and California Pizza KitchenHand-Tossed Style pizzas.
Nestle will also revamp the packaging of its products to include tools designed to educate consumers on portion sizes and the importance of balancing their plate with fruits and vegetables.