US Foods is planning to close its distribution center in Severn, Anne Arundel County, in the US state of Maryland, putting over 350 jobs at risk.
The operations from the Severn facility will be moved to other facilities including a center in Manassas, Virginia.
Commenting on the closure, US Foods spokeswoman Michelle Calcagni said: "This tentative decision was made after a thorough review of our distribution network serving the Washington, D.C., metropolitan area revealed that we can provide the same high level of service to our customers in a much more cost-effective manner."
The closure of US Foods' facility is the latest in the series of closures announced by various companies in the state including Unilever in Baltimore; Safran Labinal Power Systems in Salisbury; and Diageo.
In 2013, food distributor Sysco announced plans to acquire US Foods for $3.5bn.
However, Maryland, nine other states, the District of Columbia and the Federal Trade Commission had opposed the merger, as the deal could result in increased prices by reducing competition in the market.