The Supreme People's Procuratorate (SPP) said on Wednesday that 652 officials were investigated over misconduct in food safety protection from January 2014 to June 2015.
The officials involved in 429 cases are largely charged with dereliction of duty, abuse of power, embezzlement and taking bribes, said Huo Yapeng with the SPP.
It is difficult to detect law enforcement officials' malpractice, but such crimes have posed a huge threat to the public's health, said Huo.
Procuratorates across the country have tightened supervision over procedures such as licensing and approving use of additives in a bid to crack down on illegal activities by food safety watchdogs.
The SPP also launched a two-year campaign to curb food and drug safety crimes.